Transplantation of Frozen Thawed Ovarian Tissue Demonstrates High Reproductive Performance and the Need to Revise Restrictive Criteria
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- menstrual bleeding (yes/no)
研究概览
简要总结
Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive.
Interventions: Ovarian tissue cryopreservation (OTCP) and transplantation, endocrine monitoring, IVF.
详细描述
Main Outcomes expected:
Endocrine profile IVF results, pregnancy rates following transplantation of ovarian tissue live-births rates following transplantation of ovarian tissue cancer disease recurrence
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •infertile patients who stored ovarian tissue to preserve fertility prior to potentially sterilizing cancer treatments
排除标准
- •active disease, fertile patients post cancer treatment
结局指标
主要结局
menstrual bleeding (yes/no)
时间窗: up to one year
recurrence of menstrual bleeding- yes or no
number of oocytes per IVF cycle
时间窗: through study completion (up to 11 years following transplantation)
number of aspirated oovytes per one IVF cycle performed
pregnancies
时间窗: through study completion (up to 11 years following transplantation)
spontaneous or post IVF pregnancy rates (%)
live births
时间窗: through study completion (up to 11 years following transplantation)
live birth rates (%)
次要结局
- disease reccurence(through study completion (7 months to 141 months following transplantation))
研究者
Prof. Dror Meirow
professor
Sheba Medical Center