To explore the mechanism of acupuncture treatment on prethrombotic state of repeated implant failure based on microrna-451a regulating IL6 / STAT pathway

Phase 1

Recruiting

• Conditions: repeated implantation failure

• Registration Number: ITMCTR2100004266
• Lead Sponsor: Fujian Maternity and Child Health Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

(l) Patients who meet the diagnostic criteria of Western medicine and traditional Chinese medicine;
(2) After oocyte retrieval, the patients who have obtained the embryo quality of 1-2 grade;
(3) The age ranged from 20 to 40 years old.

Exclusion Criteria

(1) Organic diseases or other endocrine diseases were excluded: female genital malformations, including uterine malformations (single horn uterus, bicornate uterus, mediastinal uterus and double uterus), adenomyosis, submucosal myoma and intrauterine adhesions, etc.; reproductive endocrinopathy and autoimmune diseases such as hyperprolactinemia and thyroid dysfunction;
(2) Patients with primary diseases such as liver and kidney, cerebrovascular, cardiovascular and hematopoiesis disorders, psychotic patients, allergic to aspirin or other salicylates or other components of drugs, patients with history of gastric and duodenal ulcer or gastrointestinal bleeding or other situations where aspirin is prohibited;
(3) Incomplete data affect the judgment;
(4) Those who can't adhere to the course of treatment, drop out or lose the interview;
(5) In the experiment, serious complications occurred.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microrna-451a, Jak and stat gene transfer levels;Safety inspection index;TCM symptom score;Coagulation related indicators;Serum Jak and STAT protein levels;