Metabolic Substrate Support and Tight Glycaemic control in Abdominal Aortic Aneurysm (AAA) Repair

Department of Health0 个研究点目标入组 60 人开始时间: 2004年9月30日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•60 patients requiring elective infra-renal aortic surgery for aneurysm disease will be recruited over 18 months in the Department of Vascular Surgery. All 60 patients will be randomised to receive the study solution either ALK or normal saline control.
•A further group of 30 patients (age and sex matched controls) undergoing elective abdominal, non vascular surgery will also be studied. They will not have any therapeutic interventions but will be managed as per usual by the medical teams looking after them. Cardiac and skeletal muscle damage and systemic inflammation will be measured in these patients for up to 5 days post operatively.

•1. Pregnancy
•2. Patients <18 years old
•3. Patients with Diabetes Mellitus
•4. Patients who have not given informed consent
•5. Patients who are unable to give informed consent
•6. Patients with a preoperative haemoglobin of <11 g/dl
•7. Patients undergoing emergency surgery for ruptured abdominal aortic aneurysm
•8. Patients with a history of sensitivity reaction to the solutions under study
•9. Patients participating in another study
•10. Patients with renal impairment. creatinine >200 gmol/I

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