Relationship Between Neuroinflammatory Biomarkers and Postoperative Delirium in Elderly Patients With Hip Replacement
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- neuroinflammatory biomarkers
研究概览
简要总结
This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method to predict whether patients will develop postoperative delirium and improve the prognosis of elderly patients with postoperative delirium. Reduce the probability of postoperative complications, improve the long-term survival rate of patients after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing hip replacement under spinal anesthesia
- •ASA grade I~III;
- •Voluntarily participate in this study, and informed consent was signed by the patients themselves and their families
排除标准
- •Patients with multiple fractures and trauma
- •Patients with preoperative cognitive dysfunction determined by MMSE scale;
- •Severe impairment of hearing, visual and language system functions;
- •Not suitable for or unwilling to undergo subarachnoid anesthesia
- •Patients who refuse to participate or cannot cooperate.
结局指标
主要结局
neuroinflammatory biomarkers
时间窗: preoperative、24 hours after surgery、48 hours after surgery
Whether there are changes in neuroinflammatory biomarkers(Ykl40(pg/mL), procalcitonin(ng/mL), IL-17A,IL-23,INF-γ(IU), Tau(pg/mL), amyloid beta(pg/mL),etc) in cerebrospinal fluid and plasma between delirium patients and non-delirium patients before and after operation.
次要结局
未报告次要终点