Relationship Between Neuroinflammatory Biomarkers and Postoperative Delirium in Elderly Patients With Hip Replacement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- Henan Provincial People's Hospital
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- neuroinflammatory biomarkers
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This study intends to verify and explore the correlation of neuroinflammation biomarkers in cerebrospinal fluid and plasma of elderly patients undergoing hip replacement with postoperative delirium, so as to achieve a new method to predict whether patients will develop postoperative delirium and improve the prognosis of elderly patients with postoperative delirium. Reduce the probability of postoperative complications, improve the long-term survival rate of patients after surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing hip replacement under spinal anesthesia
- •ASA grade I\~III;
- •Voluntarily participate in this study, and informed consent was signed by the patients themselves and their families
Exclusion Criteria
- •Patients with multiple fractures and trauma
- •Patients with preoperative cognitive dysfunction determined by MMSE scale;
- •Severe impairment of hearing, visual and language system functions;
- •Not suitable for or unwilling to undergo subarachnoid anesthesia
- •Patients who refuse to participate or cannot cooperate.
Outcomes
Primary Outcomes
neuroinflammatory biomarkers
Time Frame: preoperative、24 hours after surgery、48 hours after surgery
Whether there are changes in neuroinflammatory biomarkers(Ykl40(pg/mL), procalcitonin(ng/mL), IL-17A,IL-23,INF-γ(IU), Tau(pg/mL), amyloid beta(pg/mL),etc) in cerebrospinal fluid and plasma between delirium patients and non-delirium patients before and after operation.