Induction Of Mixed Haematopoietic Chimerism In Patients Using Fludarabine, Low Dose Total Body Irradiation, Peripheral Blood Stem Cell Infusion And Post-Transplant Immunosuppression With Cyclosporine And Mycophenolate Mofetil

Phase 2

Active, not recruiting

• Conditions: Myelodysplastic syndromes.; Myeloproliferative syndromes.; Acute Leukemia with < 10% blasts.; Amyloidosis; Hodgkins disease.; Multiple Myeloma; Non-Hodgkins lymphoma; Chronic myeloid leukaemia; Chronic lymphocytic leukaemia; Renal cell carcinoma

• Registration Number: ACTRN12605000380695
• Lead Sponsor: A/Prof Durrant

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-13
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients with haematological malignancy or metastatic renal cancer who are not eligible for a curative autologous transplantation or who have failed prior autologous transplantation and are not suitable for ablative conditioning regimes due to a high risk of treatment related morbidity/mortality (eg age, prior autologous transplant, pre-existing medical conditions). Patients with NHL and CLL must have failed prior therapy with an alkylating agent and/or fludarabine, or be at high risk of relapse. Patients with multiple myeloma must have stage II or III disease and received prior chemotherapy.

Exclusion Criteria

No exclusion criteria

Study & Design

• Study Type: Interventional
• Study Design: Not specified