Feasibility of Partial Nephrectomy (PN) in Clear Cell Renal Cell Carcinoma (cRCC) after down-staging with neo-adjuvant Pazopanib in patient not otherwise suitable to P

AIIMS Bhubaneswar0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•1. Expected reduction of GFR less than 30 ml/minute/1.73 m2 after RN or PN and/or
•2) Not suitable for PN due to large tumors size (4 - 7cm) and/or high complexity (R.E.N.A.L. score 10 to 12) and/or hilar tumors location.
•3. Histological verification of cRCC.
•4. Non- metastatic disease
•5.Written informed consent.

•1. Known or suspected allergy to pazopanib
•2. History of cerebrovascular accident including transient ischemic attack (TIA), pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months.
•3. Hypertension [defined as systolic blood pressure of >=140 mmHg or diastolic blood pressure of >= 90 mmHg in spite of optimal medical management.

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