Structural Cartography of the Insula in Temporal Epilepsy Patients

• Conditions: Epilepsy, Temporal Lobe; MRI Scans
• Interventions: Other: MRI

• Registration Number: NCT04871555
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Detailed Description

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Study Timeline

• Status Verified: 2021-04
• Study First Submitted: 2021-04-29
• Study First Submitted QC: 2021-04-29
• Last Update Submitted: 2021-04-29
• Study First Posted: 2021-05-04
• Last Update Posted: 2021-05-04
• Study Start: 2021-06-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy)
• patients who underwent video EEG monitoring with recorded seizures (at least one)
• patients who underwent a brain MRI with DTI sequence before epilepsy surgery
• patients who did not refuse the use of their clinical and MRI data for this study

Exclusion Criteria

• patients younger than 15 years old
• patients with previous brain surgery (before MRI)
• uncompleted MRI sequences (DTI, T1 anatomical)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
mesio-temporal epilepsy	MRI	patients suffering from mesiotemporal epilepsy type
operculo insular epilepsy	MRI	patients suffering from operculo insular epilepsy type
healthy subjects	MRI	non epileptic patients
basal temporal epilepsy	MRI	patients suffering from basal temporal epilepsy type
temporal lateral epilepsy	MRI	patients suffering from temporal lateral epilepsy type
temporo-insular epilepsy	MRI	patients suffering from temporo- insular epilepsy type

Primary Outcome Measures

Name	Time	Method
cartography of insula in temporal epilepsy patients	1 year after the last inclusion	Compared with healthy group, definition of different patterns of insular structural connectivity in epileptic patients

Secondary Outcome Measures

Name	Time	Method
Correlation structural cartography and electroclinical data	1 year after the last inclusion	correlation between patterns of insular structural connectivity and subtypes of epilepsy defined by electroclinical data

Trial Locations

Locations (1)

Central Hospital nancy; 🇫🇷 Nancy, France