FokI Vitamin D Receptor Gene Polymorphism and its correlation with precancerous lesions
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- To analyse the oral health and its correlation with the rs2228570 single-nucleotide polymorphism in healthy individuals and individuals with precancerous lesions.
研究概览
简要总结
The FokI polymorphism in the Vitamin D Receptor (VDR) gene has been investigated for its potential role in susceptibility to various precancerous lesions, including oral leukoplakia, cervical dysplasia, colorectal adenomas, and others. This polymorphism results in structural changes in the VDR protein, influencing its ability to mediate the biological effects of vitamin D, such as cell proliferation, differentiation, and apoptosis. Several studies suggest that specific variants of the FokI polymorphism may alter cancer risk by affecting these cellular processes, thus establishing a genetic predisposition in the development of precancerous conditions. However, the correlation may vary across populations and lesion types, warranting further research for conclusive evidence.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Participants with and without precancerous lesions Healthy individuals who are under taking any nutriti onal supplements and are free from systemic diseases.
排除标准
- •Subjects with a former positive history of other types of cancer or any type of systemic infections, endocrinological, metabolic, and inflammatory disease.
- •Patients with lipid-lowering drugs, oral antioxidants, or vitamin supplements.
结局指标
主要结局
To analyse the oral health and its correlation with the rs2228570 single-nucleotide polymorphism in healthy individuals and individuals with precancerous lesions.
时间窗: Baseline
次要结局
- To compare the distribution & frequency of the rs2228570 polymorphism between healthy individuals & those with precancerous lesions.(baseline)
研究者
Prof Dr Mithra N Hegde
AB Shetty Memorial Institute of Dental Sciences