Target-controlled infusion of dexmedetomidine during surgery
Not Applicable
- Conditions
- Surgical patients who undergo dexmedetomidine sedation
- Registration Number
- JPRN-UMIN000011268
- Lead Sponsor
- Fukushima Medical University
- Brief Summary
In patients under spinal anesthesia, the clinical outcomes of dexmedetomidine in the TCI group were not significantly different compared with that in the recommended regimen group. In 16 patients, dexmedetomidine concentrations were measured to investigated predictive performances of published pharmacokinetic models. The model reported by Hannivoort performed the best. (MDPE 5.6%, MDAPE 18.1%, and wobble 6.2%).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
1)Known allergy to dexmedetomidine 2)Histories of psychoneurotic disorders 3)Psychiatric pharmacotherapy 4)Deaf 5)Sleep apnea 6)Women who are pregnant or breast-feeding
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequencies of respiratory and circulatory depression which require interventions Time to loss of responsiveness after starting infusions of dexmedetomidine and time to recovery after end of infusions
- Secondary Outcome Measures
Name Time Method Blood concentrations of dexmedetomidine during target controlled infusions and the recommended regimen by drug manufacturer External evaluation of existing pharmacokinetic models using above dataset Pharmacokinetic analysis using above data