NCT00585741TerminatedNot Applicable

Pilot Study of 18F-FLT Pet Imaging in Cancer Patients

University of Wisconsin, Madison1 site in 1 country15 target enrollmentStarted: December 1, 2006Last updated: February 23, 2012

Conditions

Interventions

Trial Snapshot

Phase: Not Applicable
Status: Terminated
Sponsor: University of Wisconsin, Madison
Enrollment: 15
Locations: 1
Primary Endpoint: To test whether the cellular response to fractionated radiotherapy leads to observable global change in the uptake of 18F-FLT as assessed by PET imaging

Study Overview Study Design Eligibility Criteria Arms & Interventions Outcomes Investigators Sites Records & Identifiers Similar Trials

Study Overview

Brief Summary

Fractionated radiotherapy induces an observable change in the proliferative activity as assessed by pre-treatment and early-treatment 18F-FLT PET imaging. This study is designed to investigate 18F-FLT as a PET imaging agent for predicting treatment effectiveness in several tumors and will serve as a pilot study to a planned PO1 submission

Study Design

Study Type: Interventional
Allocation: Non Randomized
Intervention Model: Parallel
Primary Purpose: Treatment
Masking: None

Eligibility Criteria

Ages: 18 Years to — (Adult, Older Adult)
Sex: Female
Accepts Healthy Volunteers: No

Inclusion Criteria

•Able to tolerate a PET/CT scan
•Age of 18 or older
•signed informed consent
•being considered for radiotherapy for treatment of CNS mets, Head and neck cancer, lung cancer, prostate cancer or esophageal cancer

Exclusion Criteria

•Prior XRT to site being studied
•severe claustrophobia or inability to tolerate PET/CT
•unable to provide written consent
•pregnant or breastfeeding women