Intranasal Insulin and Memory in Early Alzheimer's Disease
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- fMRI Measure of Hippocampal Activation
研究概览
简要总结
To determine which parts of the brain are involved in insulin-related memory improvement in early Alzheimer's disease and cognitively normal older adults.
详细描述
Functional MRI study to characterize the neuroanatomic correlates of acute exogenous insulin-related improvements in cognitive performance in early Alzheimer's disease and cognitively normal older adults. The role of the apoE-e4 allele in modulating brain insulin responses is also addressed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with Early Alzheimer's disease
排除标准
- •Patients with Late Alzheimer's disease
研究组 & 干预措施
Intranasal Insulin Aspart
Participants were administered intranasal insulin aspart (40 IU) in a double-blinded fashion approximately 30 minutes prior to functional MRI scanning. After a washout period of 48 hours, participants completed the other arm. The order of saline vs. insulin was counterbalanced.
干预措施: Insulin Aspart (Drug)
Intranasal Saline (placebo)
Participants were administered intranasal saline (placebo) in a double-blinded fashion approximately 30 minutes prior to functional MRI scanning. After a washout period of 48 hours, participants completed the other arm. The order of saline vs. insulin was counterbalanced.
干预措施: Placebo (Drug)
结局指标
主要结局
fMRI Measure of Hippocampal Activation
时间窗: 30 minutes After Intervention Administration
Percentage active voxels of total hippocampal volume of interest
次要结局
- Global Cognition(90 mins)
研究者
Jeff Burns, MD
Professor, Associate Director University of Kansas Alzheimer's Disease Center
University of Kansas Medical Center