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临床试验/NCT03651817
NCT03651817已完成不适用

Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg

Kocaeli University1 个研究点 分布在 1 个国家目标入组 32 人开始时间: 2018年10月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
32
试验地点
1
主要终点
Change of arterial carbondiokside pressure levels

研究概览

简要总结

Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Undergoing Cardiopulmonary bypass

排除标准

  • Severe COPD
  • Chronic Anemia
  • Active Smoker
  • Chronic kidney Disease

结局指标

主要结局

Change of arterial carbondiokside pressure levels

时间窗: from the beginning of operation to 6th hour of post-extubation

Investigators will compare the changes in arterial carbondiokside levels in arterial blood gas samples

次要结局

  • Changes in respiratory parameters(from the beginning of the operation to the end of the surgery)
  • Changes in Invasive blood pressures(from the beginning of the operation to the end of the surgery)
  • Changes in heart rate(from the beginning of the operation to the end of the surgery)
  • Changes in central venous pressure(from the beginning of the operation to the end of the surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Tülay Çardaközü

Associate Professor

Kocaeli University

研究点 (1)

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