Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation

Not Applicable

Completed

• Conditions: Postoperative Ileus
• Interventions: Other: gum chewing; Other: Control

• Registration Number: NCT01956643
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Postoperative ileus is a common after abdominal surgery. Multifactorial etiology such as surgical trauma, bowel manipulation and perioperative opioids contributes to delayed return of normal gut function Chewing gum has recently been used as a form of sham feeding to stimulate acceleration of gut function after abdominal surgery.

The investigators hypothesize that sham feeding with chewing gum will accelerate return of gut function after liver transplantation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-09-27
• Study Start: 2013-10
• Study First Submitted QC: 2013-10-07
• Study First Posted: 2013-10-08
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-23
• Last Update Posted: 2019-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• elective liver transplantation surgery
• an ability to chew gum

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Exclusion Criteria

• emergency surgery
• age less than 18 years,
• inability to provide written informed consent
• an inability to chew gum
• hepaticojejunostomy
• sedated patients
• reintubated patients
• Glasgow Coma Scale <13
• reoperation before gas out
• previous bowel surgery

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
gum chewing	gum chewing	Gum type was standardized with all subjects receiving sugar-free xylitol gum. The patients in the chewing gum group, gum chewing began the morning of postoperative day 1. Patients chewed gum (two tablets) 3 times daily in the morning, afternoon, and evening for 15 min. The administration of the therapy was implemented by ICU nurses and recorded in the clinical report form file. All gum-chewing patients completed their course of gum chewing until gas out.
Control	Control	Routine care during NPO

Primary Outcome Measures

Name	Time	Method
time to flatus	an expected average of 75 hours

Secondary Outcome Measures

Name	Time	Method
percentage of target calories	an average 4 days
ICU length of stay	an average 96 hous
hospital length of stay	an average 20 days

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of