Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- time to flatus
研究概览
简要总结
Postoperative ileus is a common after abdominal surgery. Multifactorial etiology such as surgical trauma, bowel manipulation and perioperative opioids contributes to delayed return of normal gut function Chewing gum has recently been used as a form of sham feeding to stimulate acceleration of gut function after abdominal surgery.
The investigators hypothesize that sham feeding with chewing gum will accelerate return of gut function after liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective liver transplantation surgery
- •an ability to chew gum
排除标准
- •emergency surgery
- •age less than 18 years,
- •inability to provide written informed consent
- •an inability to chew gum
- •hepaticojejunostomy
- •sedated patients
- •reintubated patients
- •Glasgow Coma Scale <13
- •reoperation before gas out
- •previous bowel surgery
研究组 & 干预措施
gum chewing
Gum type was standardized with all subjects receiving sugar-free xylitol gum.
The patients in the chewing gum group, gum chewing began the morning of postoperative day 1. Patients chewed gum (two tablets) 3 times daily in the morning, afternoon, and evening for 15 min. The administration of the therapy was implemented by ICU nurses and recorded in the clinical report form file. All gum-chewing patients completed their course of gum chewing until gas out.
干预措施: gum chewing (Other)
Control
Routine care during NPO
干预措施: Control (Other)
结局指标
主要结局
time to flatus
时间窗: an expected average of 75 hours
次要结局
- percentage of target calories(an average 4 days)
- ICU length of stay(an average 96 hous)
- hospital length of stay(an average 20 days)
研究者
Ho Geol Ryu
Assistant Professor
Seoul National University Hospital