A randomised clinical trial on the effects of two different doses of dexmedetomidine infusion on haemodynamic stress response, sedation and postoperative analgesia requirement in patients undergoing laparoscopic cholecystectomy.

The study will be conducted on “A randomised clinical trial on the effects of two different doses of dexmedetomidine infusion on haemodynamic stress response, sedation and post-operative analgesia requirement in patients undergoing laparoscopic cholecystectomy”. Here, in our study we will compare the infusion of two low doses of dexmedetomidine with an aim to assess the effect on haemodynamic stress response, sedation during the surgical procedure. We will also try to find out the post-operative analgesia requirement. A total of 64, aged 18 to 65 years belonging to American society of Anaesthesiologists (ASA) I and II, undergoing laparoscopic cholecystectomy under general anaesthesia will be divided into two groups (Group A, group B) by block randomization. Group A patients will receive dexmedetomidine 0.2 mcg/kg/h as intravenous infusion, group B patients will receive dexmedetomidine 0.4 mcg/kg/h as intravenous infusion. Hemodynamic parameters will be monitored and recorded during before starting the infusion, 15 min after starting the infusion, after induction, after intubation, after creation and release of pneumoperitoneum and after extubation. Patients were also observed for time to extubate trachea, post-operative sedation level, time to first rescue analgesic requirement, total amount of analgesic drug required during the first 24 h post-operatively and the adverse effects. The findings and observations made during the entire study will be tabulated, graphically depicted whenever possible, statistically analyzed and inference will be drawn.