Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

Withdrawn

• Conditions: Acute Kidney Injury

• Registration Number: NCT02188602
• Lead Sponsor: Stanford University

Brief Summary

The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients. The investigators hypothesis is that administering intravenous fluids with higher chloride content are more likely to lead to acute kidney injury.

Detailed Description

Retrospective chart review from 2008-2012 evaluating chloride dosing and serum chloride levels and their effects on acute kidney injury in the pediatric ICU. Patients will be included for the first seven days of their PICU stay.

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2013-07-19
• Study First Submitted QC: 2014-07-10
• Study First Posted: 2014-07-11
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-17
• Last Update Posted: 2022-08-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• age less than 18 years
• PICU admitting diagnosis of sepsis, respiratory failure, or hepatic failure.

Exclusion Criteria

• hyponatremia or hypernatremia at PICU admission
• preexisting diagnosis of End-stage renal disease or renal transplant
• presence of neurologic comorbidities.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute Kidney Injury	7 days	or sooner if death or discharged

Secondary Outcome Measures

Name	Time	Method
Hospital length of stay	7 days
Mortality	7 days
Number of ventilator days	7 days
PICU length of stay	7 days

Trial Locations

Locations (1)

Lucile Packard Children's Hospital; 🇺🇸 Palo Alto, California, United States