Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)

Not Applicable

Completed

• Conditions: Anemia; Malaria, Falciparum
• Interventions: Device: Insecticide treated wall lining

• Registration Number: NCT02448745
• Lead Sponsor: The Mentor Initiative

Brief Summary

A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia. Half of the villages enrolled in the study will receive insecticide-treated wall lining covering their walls and ceilings in addition to long-lasting insecticidal nets, while the other half will be protected by existing long-lasting insecticidal nets.

Detailed Description

Long-lasting insecticidal nets (LLINs) are the established vector control product for malaria control. In Bomi County Liberia, LLINs have been distributed but malaria prevalence in children under 5 remains high, with prevalence in study villages found to be 42% in April 2014. The major malaria vector species are resistant to pyrethroid insecticides approved for use in LLINs, and new control measures with non-pyrethroid active ingredients may protect the population.

Study Timeline

• Study Start: 2014-03-01
• Study First Submitted: 2015-05-15
• Study First Submitted QC: 2015-05-15
• Study First Posted: 2015-05-19
• Primary Completion: 2016-06-01
• Study Completion: 2017-04-01
• Status Verified: 2018-04
• Last Update Submitted: 2018-04-27
• Last Update Posted: 2018-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6317

Inclusion Criteria

• Child resides in village
• Child presents with parent or guardian

Exclusion Criteria

• Child or guardian has history of Ebola exposure
• Child has 3 symptoms of Ebola

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	Insecticide treated wall lining	21 clusters composed of one or more villages with a total of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is available and in addition insecticide treated wall lining is installed in all sleeping areas with homeowner consent. All 4 walls and the ceiling are covered with lining.

Primary Outcome Measures

Name	Time	Method
Malaria Prevalence	6 months	Tested by mRDT and PCR

Secondary Outcome Measures

Name	Time	Method
Fever	6 months	Number of participants with Fever, defined as tympanic temperature above 37.5C
Mosquito biting rate.	2 months	Mosquitoes trapped indoors and outdoors using light traps and exit traps.
Hemoglobin	6 months	Hemoglobin measured by Hemocue 301

Trial Locations

Locations (1)

Bomi County Health Team; 🇱🇷 Tubmanburg, Bomi County, Liberia