The study of the significance of the phosphorylation of p53 Ser46 in the prediction of response to preoperative chemotherapy or chemoradiotherapy for advanced esophageal cancer
- Conditions
- Advanced esophageal squamous cell carcinoma which are scheduled to undergo chwemotherapy or chemoradiotherapy as an initial treatment
- Registration Number
- JPRN-UMIN000016535
- Lead Sponsor
- Kindai University, Faculty of Medicine, Department of Surgery
- Brief Summary
In this study, we examined the usefulness of induction of the phosphorylation of p53-Ser46 the next day after initiation of treatment as a biomarker of the prediction of treatment response of chemotherapy/chemoradiotherapy for esophageal squamous cell carcinoma. We confirmed the fact for the first time that the phosphorylation of p53-Ser-46 was induced by chemotherapy/chemoradiotherapy in the early stage of treatment. However, there was no significant correlation between the phosphorylation of p-53-Ser-46 and treatment response. Among cases obtained complete response to preoperative therapy, the cases with p-53 mutant and no induction of Ser-46 phosphorylation were involved, therefore, these results suggested that the effect on chemotherapy and chemoradiotherapy was caused not only by apoptosis thorough p53 pathway, but also by another pathway associating with other factors.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Not provided
1. another malignat disease to need treatment 2. past hostory of severe drug hypersensitivity 3. pregnant female, nursing mother and women who have childbearing potential and are considering pregnancy. 4. doctor rules unfit for enrollment of this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the correlation between the phosphorylation of P53 Ser-46 and complete response to therapy
- Secondary Outcome Measures
Name Time Method 1. the correlation between the phosphorylation of P53 Ser-46 and clinical good response (CR and PR) 2. the correlation between the phosphorylation of P53 Ser-46 and histological complete response 3. the correlation between the phosphorylation of P53 Ser-46 and P53 genotype 4. the correlation between the phosphorylation of P53 Ser-46 and the prognosis 5. the correlation between the phosphorylation of P53 Ser-46 and failure patterns 6. the comparison of P53 status in pretreatment tumor and residual or local recurrent tumor after treatment