Randomised control trial of monoamine precursors for the treatment of psychostimulant withdrawal

Phase 3

Completed

• Conditions: Psychostimulant withdrawal; Mental Health - Addiction

• Registration Number: ACTRN12607000094471
• Lead Sponsor: Sydney South West Area Health Service

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-01-29
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Inclusion Criteria 1. DSM-IV Classification of Amphetamine or Cocaine Dependence / Severity of Dependence Scale (SDS) score greater than 4. 2. Psychostimulant use at least 2 times per week with at least 3 month history.

Exclusion Criteria

Exclusion Criteria 1.Alcohol dependence (AUDIT) 2. Use of drugs other than psychostimulants 4 times a week or more (nicotine dependence is permitted)3. Amino acid contraindications (eg., phenylketonuria) 4. Malabsorption medical conditions (eg., Crohn’s disease, ulcerative colitis) 5. Currently prescribed antidepressant / mood stabilising / antipsychotic medications 6. Current suicidal ideation 7. History of schizophrenia / other psychotic illness 8. Hospitalisation in the past 12 months for more than 24 hours for psychiatric symptoms including hallucinations, delusions and suicidal ideation 9. Elevated Liver Function Tests (3 times higher than normal levels) 10. Currently pregnant or likely to become pregnant in the following month.

Study & Design

• Study Type: Interventional
• Study Design: Not specified