Role of Procalcitonin in guiding antibiotic therapy in moderate to severe acute pancreatitis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- NA
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- To assess the procalcitonin level for Antibiotic usage during the admission period
研究概览
简要总结
After obtaining written informed consent and checking for exclusion criteria ,patients with acute pancreatitis will be enrolled in the study on day 0 of acute pancreatitis.
In brief, per protocol procalcitonin testing will be conducted on days 0, 7 ,14 and at any time before starting the antibiotics.
The threshold for a positive procalcitonin test for this study is 1·0 ng/mL. Guidance is to start antibiotics following a test value of 1·0 ng/mL or more.
Procalcitonin measurement-based guidance is one of a range of clinical considerations informing antibiotic management. In the enrolled patients, any empirical clinical decision to use antibiotics is
preceded by measurement of procalcitonin. If the concentration is less than 1·0 ng/mL, antibiotics will not be used unless there is a clinically relevant positive microbiology result.
Standard care followed the current International Association of Pancreatology/American Pancreatic Association guidelines for the management of patients with acute pancreatitis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with the confirm diagnosis of moderate and severe acute pancreatitis.
排除标准
- •Admitted after 1 week of acute pancreatitis Patient on antibiotic.
结局指标
主要结局
To assess the procalcitonin level for Antibiotic usage during the admission period
时间窗: 0,7,14 days
次要结局
- Profile of infection, intervention and outcome in moderate to severe acute pancreatitis(0,7,14 days)
研究者
Dr Ganesh Bhat
Department of gastroenterology and hepatology