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Clinical Trials/NCT06869070
NCT06869070Not yet recruitingNot Applicable

Optimisation and Standardization of Circulating Cell-free DNA Ex-traction Protocols in a Diagnostic Setting

University Hospital Tuebingen0 sites10 target enrollmentStarted: April 7, 2025Last updated:
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Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
10
Primary Endpoint
cfDNA quantity
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

comparison of blood collection tubes and cell-free DNA extraction to evaluate the best possible combination to obtain high quantity and quality cell-free DNA sample for NGS analyses

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •at least 18 years
  • •no serious condition

Exclusion Criteria

  • •younger than 18 years
  • •serious health condition that leads to higher cfDNA content in blood

Outcomes

Primary Outcomes

cfDNA quantity

Time Frame: Baseline, at enrollment

we will assess the quantities in ng/µl of cell-free DNA extracted from plasma

cfDNA quality

Time Frame: Baseline, at enrollment

we will assess the fragments length in nucleotides using TermoFisher's Tapestation from the extracted plasma cell-free DNA

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

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