Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
- Conditions
- Peripheral Arterial Occlusive Disease
- Registration Number
- NCT01087385
- Lead Sponsor
- University Heart Center Freiburg - Bad Krozingen
- Brief Summary
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
- Detailed Description
Troponin T and I are established risk markers in patients with acute coronary syndrome. Only recently, troponin I was found to be elevated in patients with acute critical limb ischaemia. In another study, troponin I was associated with a higher mortality in patients with chronic critical limb ischaemia followed over two years. In a longitudinal study design we intend to follow all patients that were treated for symptomatic PAOD (Fontaine stages II-IV) from 01/2007 to 12/2007 in our department of angiology. Main outcome parameters are death and the occurrence of major vascular events and revascularization procedures during follow-up.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1000
- symptomatic peripheral arterial occlusive disease
- aged >/= 18 years
- unstable angina or acute coronary syndrome < 14 days
- percutaneous coronary intervention < 14 days
- other interventions or disease associated with troponin T release (i.e., acute pulmonary embolism, aortic dissection, heart valve replacement, acute heart failure, non-ischemic cardiomyopathy, heart surgery, thoracic trauma, endocarditis, myocarditis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Death 1 year
- Secondary Outcome Measures
Name Time Method Myocardial infarction, acute coronary syndrome, percutaneous coronary intervention, stroke, amputation, peripheral revascularization, target limb revascularization, target vessel revascularization 1 year
Trial Locations
- Locations (1)
Angiologie, Herzzentrum Bad Krozingen
🇩🇪Bad Krozingen, Germany