Rumination-Focused Cognitive Behavioural Therapy for residual depressio

Completed

Conditions: Residual treatment-resistant depression
Mental and Behavioural Disorders

Registration Number: ISRCTN22782150

Lead Sponsor: niversity of Exeter (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 42

Inclusion Criteria

1. Aged >18
2. Meeting criteria for medication-refractory residual depression defined as:
2.1. Meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for major depression within the last 18 months but not in the last 2 months
2.2. Residual symptoms reaching at least 8 on the 17-item Hamilton Depression Rating Scale (HRSD) and 9 on the Beck Depression Inventory (BDI-II)
2.3. Taking antidepressant medication at a therapeutic dose as recommended by the British National Formulary and/or equivalent to 125mg of amitriptyline for at least 8 weeks continuously during the current episode and within the last 2 months

Exclusion Criteria

1. A history of bipolar disorder, psychosis
2. Current drug or alcohol dependence
3. Learning disability
4. Organic brain damage
5. Concurrent psychotherapy at point of entry to the study

There were no exclusion criteria with respect to co-morbid anxiety disorders or Axis II diagnosis

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Hamilton Rating Scale for Depression (HRSD) <br>2. Beck Depression Inventory (BDI-II)

Secondary Outcome Measures

Name	Time	Method
1. The Structured Clinical Interview for DSM-IV (SCID) to assess diagnostic status for major depression<br>2. Ruminative Response Scale of the Response Styles Questionnaire (RRS) to assess rumination