The Effects of a Train High, Sleep Low Strategy

Not Applicable

Completed

• Conditions: Cycling Performance; Muscular Adaptations; Substrate Utilization
• Interventions: Other: Combined exercise and diet intervention

• Registration Number: NCT03045588
• Lead Sponsor: University of Aarhus

Brief Summary

The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-01
• Primary Completion: 2016-12-20
• Study First Submitted: 2017-01-29
• Study First Submitted QC: 2017-02-06
• Study First Posted: 2017-02-07
• Status Verified: 2018-10
• Study Completion: 2018-10-10
• Last Update Submitted: 2018-10-23
• Last Update Posted: 2018-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• 18-45 years
• VO2-max>55 ml/kg/min
• No smokers
• Training 6 hours per week (cycling)
• Training experience for more than 3 years.

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Exclusion Criteria

• Less than 2 g carbohydrate/kg/day

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low group	Combined exercise and diet intervention	This subjects in this group conducts all their morning exercise sessions with high fat oxidation (in a fasted condition). Thus, the subjects in this group after high intensity exercise in the evening do not get any carbohydrates to eat after training until the exercise session the following morning has been conducted.
High group	Combined exercise and diet intervention	This subjects in this group conducts all their morning exercise sessions with low fat oxidation (in a fed condition). Thus, the subjects in this group after high intensity exercise in the evening do get carbohydrates to eat after training until the exercise session the following morning has been conducted.

Primary Outcome Measures

Name	Time	Method
Time trial performance measured in Watts	Change from Baseline and after 4 weeks of training	30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.

Secondary Outcome Measures

Name	Time	Method
Protein expression in skeletal muscle tissue	Baseline and after 4 weeks of training	Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique
The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute	Baseline and after 4 weeks of training	Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry.