Multimodal Assessment of Neurobiological Markers for Psychiatric Disorders
Overview
- Phase
- Phase 4
- Intervention
- Escitalopram
- Conditions
- Major Depressive Disorder (MDD)
- Sponsor
- Medical University of Vienna
- Enrollment
- 289
- Locations
- 1
- Primary Endpoint
- SSRI induced changes in BOLD (blood oxygen level dependent) response over time
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
MAN-BIOPSY pursues the concrete research question whether novel biological and psycho-physiological clusters or categories can be defined to improve treatment and minimize side effects in psychiatry, based on a synopsis of physiological, behavioural, genetic and endocrinological parameters. One major aspect of our research approach is its focuses on the identification of dysfunctions in fundamental information processing mechanisms and neurocomputational mechanisms, and is not restricted to symptom-oriented tasks.
The main objectives of MAN-BIOPSY are therefore
- to identify biological and psycho-physiological parameters for major depressive disorders and anxiety disorders, and
- to identify predictive markers for treatment response and type/severity of side effects for these disorders.
Investigators
Rupert Lanzenberger
A/Prof.PD.Dr.
Medical University of Vienna
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •concomitant major internal or neurological illness
- •concomitant psychiatric disorders (except depression and anxiety for patients, excluding PTSD, claustrophobia and bipolar disorder)
- •ingestion of any antipsychotic, antidepressant, or anti-anxiety agent within the last three months prior to the screening visit
- •current substance abuse
- •failure to comply with the study protocol or to follow the instructions of the investigating team
Arms & Interventions
Escitalopram
50 Major Depressive Disorder Patients and 50 Anxiety Disorder Patients will receive Escitalopram as medication
Intervention: Escitalopram
Outcomes
Primary Outcomes
SSRI induced changes in BOLD (blood oxygen level dependent) response over time
Time Frame: 4 vears
SSRI induced changes in ERPs (event-related potentials) over time
Time Frame: 4 years
Secondary Outcomes
- biochemical data(4 years)