Multimodal Assessment of Neurobiological Markers for Psychiatric Disorders
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 289
- 试验地点
- 1
- 主要终点
- SSRI induced changes in BOLD (blood oxygen level dependent) response over time
研究概览
简要总结
MAN-BIOPSY pursues the concrete research question whether novel biological and psycho-physiological clusters or categories can be defined to improve treatment and minimize side effects in psychiatry, based on a synopsis of physiological, behavioural, genetic and endocrinological parameters. One major aspect of our research approach is its focuses on the identification of dysfunctions in fundamental information processing mechanisms and neurocomputational mechanisms, and is not restricted to symptom-oriented tasks.
The main objectives of MAN-BIOPSY are therefore
- to identify biological and psycho-physiological parameters for major depressive disorders and anxiety disorders, and
- to identify predictive markers for treatment response and type/severity of side effects for these disorders.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •concomitant major internal or neurological illness
- •concomitant psychiatric disorders (except depression and anxiety for patients, excluding PTSD, claustrophobia and bipolar disorder)
- •ingestion of any antipsychotic, antidepressant, or anti-anxiety agent within the last three months prior to the screening visit
- •current substance abuse
- •failure to comply with the study protocol or to follow the instructions of the investigating team
研究组 & 干预措施
Escitalopram
50 Major Depressive Disorder Patients and 50 Anxiety Disorder Patients will receive Escitalopram as medication
干预措施: Escitalopram (Drug)
结局指标
主要结局
SSRI induced changes in BOLD (blood oxygen level dependent) response over time
时间窗: 4 vears
SSRI induced changes in ERPs (event-related potentials) over time
时间窗: 4 years
次要结局
- biochemical data(4 years)
研究者
Rupert Lanzenberger
A/Prof.PD.Dr.
Medical University of Vienna