To Assess the Correlation Between the Predictive Factor of Vascularity (CD74) in Malignant Pleural Mesothelioma and Treatment Results (Response Rate, and Overall Survival )
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- to correlate the results of the vascularity marker of pleural mesothelioma CD74 of patients attended to Ain Shams University hospitals with the result response of treatment by chemotherapy ,overall survival and progreeion free survival
研究概览
简要总结
The purpose of this study is to To assess the correlation between the predictive factor of vascularity (CD74) in malignant pleural mesothelioma and treatment results (response rate, and overall survival) .
详细描述
This is a randomized controlled retrospective study through Examination of paraffin blocks of the patient selected to be included in the study for assessment of the selected vascularity marker of malignant pleural mesothelioma of both types . The CD74 (LN2) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed paraffin-embedded tissue sections using Immunohistochemistry test methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 39 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histopathological confirmation of malignant pleural mesothelioma .
- •Full clinical data.
- •Availability for follow up: Personal communication will be attempted in order to collect missing information.
- •3-The files of all patients will be reviewed to analyze the following :
- •Operative data if done .
- •Pathological review and immunohistochemistry.
- •Laboratory investigations: (routine investigations: complete blood picture,liver and renal function test)
- •Radiological investigations:( CXR and CT-chest, Abdominal and pelvic U\S and MRI ).
- •Treatment protocols applied: Radiotherapy and Chemotherapy.
- •Response and survival after treatment .
排除标准
- •cases not receive chemotherapy ,on available of evaluation after treatment
结局指标
主要结局
to correlate the results of the vascularity marker of pleural mesothelioma CD74 of patients attended to Ain Shams University hospitals with the result response of treatment by chemotherapy ,overall survival and progreeion free survival
时间窗: 3-4 months
The cases diagnosed and receive at the least 2-3 cycles of chemotherapy and evaluated after treatment
次要结局
- assessment of vascular enothelial growth factor (VEGF) in patient with malignant pleural mesothelioma who attended to Ain Shams University and made comparison with the result of CD 74(3-4 months)
研究者
Muna Sami Jassim
Doctor in clinical oncology and nuclear medicine department
Ain Shams University