Comparison of starting total versus minimal milk feeding in stable low birth weight babies born at or beyond 32 weeks gestation on the duration of hospital stay
- Conditions
- Other low birth weight newborn,
- Registration Number
- CTRI/2021/03/031643
- Brief Summary
Very low birth weight refers to babies with birth weight in between 1000 to 1499gm. Initiation of enteral feeds for very-low-birth weight (VLBW) infants is often delayed for several days due to concerns about feeding intolerance and necrotizing enterocolitis (NEC). The intestine of small for gestational age neonate has reduced weight, length, wall thickness, villous weight and crypt depth. Pathophysiology of fetal adaptation to chronic hypoxia involves preferential shunting of blood to the brain at the expense of the splanchnic circulation. Earlier studies had very samples from the SGA populations. Early introduction of enteral feeds resulted in early achievement of full feeds and doesn’t appear to increase the risk of NEC. This delay diminishes the functional adaptation of the gastrointestinal tract and may prolong the duration of parenteral nutrition with its attendant infectious and metabolic risks. Early introduction and rapid advancement of enteral feeding in preterm infants improves gut maturity and thus reduces the risk of NEC. So the above study shall test the hypothesis that, early total enteral feeding in these group of babies shall lead to shorter duration of hospital stay and earlier discharge.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 56
All very low birth weight and small for gestational age babies more than or equal to 32 weeks of gestation with ,Heart rate in between 100 to 180 beats/min, Respiratory rate in between 40 to 60/min, Axillary Temperature in between 36.5 to 37.5 degree C, Capillary filling time of < 3sec, Spo2 ( saturation of oxygen) in between 90 to 95%, BP (blood pressure), normal as per nomograms.
- Requiring resuscitation beyond bag and mask ventilation for 30 seconds.
- Major congenital anomalies 3.
- Babies with absent or reverse end diastolic flow in the Umbilical artery Doppler.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Duration of hospital stay From day of admission to the day of discharge.
- Secondary Outcome Measures
Name Time Method 1.Survival to hospital discharge 2.Number of episodes of Hypoglycemia
Trial Locations
- Locations (1)
NICU
🇮🇳Mumbai, MAHARASHTRA, India
NICU🇮🇳Mumbai, MAHARASHTRA, IndiaDr Swati ManerkarPrincipal investigator9769997968drswatimanerkar@gmail.com