Vasopressin in cardiac surgery
Not Applicable
- Conditions
- Health Condition 1: I501- Left ventricular failure, unspecifiedHealth Condition 2: O- Medical and SurgicalHealth Condition 3: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Planned for elective cardiac surgery with CPB and presenting with LV dysfunction preoperatively.
LV dysfunction will be identified by the presence of LV EF < 50% on the last available preoperative echocardiography report, except in patients with severe mitral regurgitation where the cutoff for LV EF will be <60%.
Exclusion Criteria
Preoperative requirement of vasopressors/inotrope/mechanical circulatory support
Pregnancy
Patients undergoing simultaneous non cardiac surgery
Patients on renal replacement therapy
Patients with model for end-stage liver disease
Patients taking drugs for thyroid or adrenal disease
Documented peripheral vascular disease disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cardiac indexTimepoint: 30 minutes post cardiopulmonary bypass
- Secondary Outcome Measures
Name Time Method Heart rate, blood pressure, inotrope dose, blood gas investigations, cardiac index, left ventricle myocardial performance index, left ventricle systolic, diastolic functionTimepoint: Baseline, 30 minutes post CPB, and 0, 6, 12 and 24 hours in ICU;Hospital stay, MortalityTimepoint: 30 days post-operatively;Mechanical ventilation duration, ICU stay, Incidence of atrial fibrillation, requirement of renal replacement therapy, incidence of acute mesentric ischemia, peripheral cyanosisTimepoint: During ICU stay