The evaluation of clinical effect of locally delivered minocycline hydrochloride in the surgical treatment of peri-implantitis

Not Applicable

Recruiting

• Conditions: Certain infectious and parasitic diseases

• Registration Number: KCT0002844
• Lead Sponsor: Yonsei University Health System, Dental Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

The following inclusion criteria were applied:
-Diagnostic criteria of peri-implantitis; peri-implant bone loss > 2mm, probing depth > 5mm, bleeding on probing/suppuration and presence of plaque (Lang et al. 2004)
-No history of active (surgical) treatment for peri-implantitis
-Bone loss that occurred apical to the reference point established based on implant system when there is no radiographic data that can be used as the baseline
The reference points according to the implant system are as follows:
Branemark type: First thread
Straumann type: 2.8mm(standard) / 1.8mm(standard plus) below the implant shoulder
Astra tech type: 1.8mm below the implant shoulder
Reference) Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitis. Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T.J Dent Res. 2016 Jan;95(1):43-9.

Exclusion Criteria

The following exclusion criteria were applied:
-Presence of pregnancy or lactation.
-Taking drugs that can affect periodontal disease (phenytoin, cyclosporine, and calcium channel blockers).
-Taking Coumadin or non-steroidal anti-inflammatory drugs.
-Presence of diabetes mellitus, smoking (except former smoking with cessation at least 10
-Those who is allergies with tetracycline.
-Those using chlorhexidine or any other mouth rinse.
-Those who have taken antibiotics within the previous 3 months.

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Probing Depth

Secondary Outcome Measures

Name	Time	Method
Bleeding on probing,;Plaque index;Bacterial analysis