Perfusion Index Variability in Respiratory Distress Syndrome
- Conditions
- Poor Peripheral Perfusion
- Interventions
- Registration Number
- NCT01852461
- Lead Sponsor
- Dr. Sami Ulus Children's Hospital
- Brief Summary
Perfusion index may vary according to type of surfactant during the treatment of respiratory distress syndrome.
- Detailed Description
Peripheral tissues of preterm infants are very sensitive for hypoperfusion, but there are rare data in the literature for peripheral perfusion after surfactant treatment. In this study the investigators aimed to compare the perfusion index (PI) variability in premature infants with respiratory distress (RDS) following instillation of one of two different natural surfactant preparations.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 92
- premature infants < 32 weeks of gestational age
- congenital malformation
- Apgar scores <3 at 5 min
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Beractant Beractant Beractant;bovine lung extract; both initial and subsequent dosing is 100 mg/kg (4 mL/kg), which may be given every 6 hours up to four total doses Poractant alfa Poractant alfa Poractant alfa; porcine lung extract; initial dosing is 200 mg/kg (2.5 mL/kg) and repeated dosing is given at 100 mg/kg (1.25 mL/kg) every 12 hours, up to maximum of two additional doses when indicated
- Primary Outcome Measures
Name Time Method perfusion index 1 week PI and oxygen saturation (SpO2) were measured by "Masimo Rainbow SET Radical-7 pulse oximeter" before and after surfactant. The effects of the two treatment regimens on PI, oxygenation and clinical outcome were compared.
- Secondary Outcome Measures
Name Time Method Duration of mechanical ventilation 4 weeks The effects of the two treatment regimens on duration of mechanical ventilation were compared