NCT00992888已完成不适用
Inflammation, Immune Activation and Portal Hypertension in Alcoholic Hepatitis. A Pato-etiological Study With Focus on the Endotoxin Pathway.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Serum endotoxin levels
研究概览
简要总结
The purpose of this study is to investigate the role of endotoxins and the endotoxin mediated immune activation pathway in patients with alcoholic hepatitis. Also, to determine the effect of Liver assist (liver dialyses) intervention on these parameters in patients with severe alcoholic hepatitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with alcoholic hepatitis based on the following criteria
- •Alcohol intake for 6 consecutive months above 40g /day, at admission or 3 months earlier.
- •Serum bilirubin level above 80 mmol/l
- •exclusion of other types of liver disease.
- •Liver biopsy when diagnosis is unclear.
排除标准
- •Heart failure
- •Pregnancy
- •non fluent danish speakers
结局指标
主要结局
Serum endotoxin levels
时间窗: one year
次要结局
- Endotoxin activation pathway proteins(1 year)
研究者
Thomas Damgaard Sandahl
Dr
University of Aarhus
研究点 (2)
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