Inflammation, Immune Activation and Portal Hypertension in Alcoholic Hepatitis
Not Applicable
Completed
- Conditions
- Alcoholic Hepatitis
- Registration Number
- NCT00992888
- Lead Sponsor
- University of Aarhus
- Brief Summary
The purpose of this study is to investigate the role of endotoxins and the endotoxin mediated immune activation pathway in patients with alcoholic hepatitis. Also, to determine the effect of Liver assist (liver dialyses) intervention on these parameters in patients with severe alcoholic hepatitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients with alcoholic hepatitis based on the following criteria
- Alcohol intake for 6 consecutive months above 40g /day, at admission or 3 months earlier.
- Serum bilirubin level above 80 mmol/l
- exclusion of other types of liver disease.
- Liver biopsy when diagnosis is unclear.
Exclusion Criteria
- Heart failure
- Pregnancy
- non fluent danish speakers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Serum endotoxin levels one year
- Secondary Outcome Measures
Name Time Method Endotoxin activation pathway proteins 1 year
Trial Locations
- Locations (1)
Department of Medicine V, Aarhus University Hospital
🇩🇰Aarhus, Denmark
Department of Medicine V, Aarhus University Hospital🇩🇰Aarhus, Denmark