Elderly Patients and COVID-19 Infection: a Cohort of Fifty Patients Over Ninety Years of Age

Completed

• Conditions: Covid19
• Interventions: Other: Data collection from medical files

• Registration Number: NCT04499300
• Lead Sponsor: Murielle Surquin

Brief Summary

SARS-CoV2 or CoVid19 disease is a newly described pathology linked to a subtype of the coronavirus family identified in China in December 2019. This pathology can present multiple clinical facets, ranging from asymptomatic forms to more commonly critical pulmonary forms called "Acute Respiratory Distress Syndrome". The elderly population is more at risk for this infection due to the senescence of the immune system, co-morbidities and poly medications. They also often present a greater state of fragility.

This study aims to report the epidemiology of the first 50 patients over 90 years of age hospitalized within the CHU Brugmann hospital.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-09
• Study First Submitted: 2020-08-03
• Study First Submitted QC: 2020-08-04
• Study First Posted: 2020-08-05
• Primary Completion: 2020-11-23
• Study Completion: 2020-11-23
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-28
• Last Update Posted: 2022-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Be over 90 years of age on the date of admission to CHU Brugmann Hospital
• Have a SARS Cov2 infection proven by antigen or RT-PCR on smear and / or typical imaging regardless of the clinical manifestation
• Have been hospitalized at CHU Brugmann between 03/01/2020 and 05/10/2020

Exclusion Criteria

None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Covid positive	Data collection from medical files	Patients over 90 years old hospitalized within the CHU Brugmann between 03/01/2020 and 05/10/2020 with SARS Cov2 infection.
Sub-group: patients who survived	Data collection from medical files	Patients over 90 years old hospitalized within the CHU Brugmann between 03/01/2020 and 05/10/2020 with SARS Cov2 infection, who survived the infection.
Sub-group: deceased patients	Data collection from medical files	Patients over 90 years old hospitalized within the CHU Brugmann between 03/01/2020 and 05/10/2020 with SARS Cov2 infection, with death as outcome.

Primary Outcome Measures

Name	Time	Method
Demographic data	5 minutes	Age, sex, ethnicity
Comorbidities	5 minutes	Smoking, Obesity, Diabetes, Arterial hypertension, Coronary pathology, Cerebrovascular disease, chronic renal failure, chronic obstructive pulmonary disease, Neoplasia, Autoimmune disease, Chronic liver disease
Blood count	5 minutes	Blood count at hospital admission or first recorded
Coagulation	5 minutes	Coagulation at hospital admission or first recorded
Renal function	5 minutes	Renal function at hospital admission or first recorded
Albumin	5 minutes	Albumin at hospital admission or first recorded
Ionogram	5 minutes	Ionogram at hospital admission or first recorded
NTproBNP	5 minutes	NTproBNP at hospital admission or first recorded
Treatments	5 minutes	Under Chronic corticosteroid therapy or Immunosuppressive therapy
Hypotension	5 minutes	Vital signs at hospital admission: Hypotension
Infectious data	5 minutes	Contact with confirmed covid person before admission, lives in a retirement home with other cases, Initial bacterial or viral co-infection, Bacterial or viral co-infection during the hospital stay
D-dimers at hospital admission or first recorded	5 minutes	D-dimers
Length of ICU Stay	5 minutes	Length of ICU Stay
Status at hospital exit	5 minutes	One of the following choices: death, went back home, went back to a retirement home, was placed in a revalidation unit.
Fever	5 minutes	Vital signs at hospital admission: Fever
Hypoxemia	5 minutes	Vital signs at hospital admission: Hypoxemia
Tachycardia	5 minutes	Vital signs at hospital admission:Tachycardia
Liver function	5 minutes	Liver function at hospital admission or first recorded
Fibrinogen	5 minutes	Fibrinogen at hospital admission or first recorded
CK	5 minutes	CK at hospital admission or first recorded
Troponin	5 minutes	Troponin at hospital admission or first recorded
Procalcitonin	5 minutes	Procalcitonin at hospital admission or first recorded
Treatment received	5 minutes	Hydroxychloroquine or Azithromycin
Mortality	5 minutes	28-day mortality after PCR / CT scan / diagnosis
Cumulative Illness Rating Scale-Geriatric (CIRS-G)	5 minutes	CIRS-G quantifies burden of disease in elderly patients (comorbidity scale). Higher scores indicate higher severity (maximum score = 56 points).
Signs and symptoms	5 minutes	Presence and date of first apparition: Fever, Cough, Dyspnea, Chest pain, Nausea or vomiting, Diarrhea, Fatigue, Anosmia, ageusia, inappetence, Confusion, Fall, Fracture
Number of pulmonary lobes affected	5 minutes	Number of pulmonary lobes affected
Ferritin	5 minutes	Ferritin at hospital admission or first recorded
Biology - highest rate	5 minutes	Highest rate of CRP, D-Dimers, Urea, Creatinin, Fibrinogen, CK, Troponins
Biology - lowest rate	5 minutes	Lowest rate of hemoglobin, platelets, leucocytes, lymphocytes, albumin, Na+, K+
Percentage of pulmonary involvement on chest CT scan	5 minutes	Percentage of pulmonary involvement on chest CT scan
Type of lesions	5 minutes	Type of lesions as reflected on the CT scan images: 'Ground glass' or 'Crazy paving'
Need for oxygenotherapy	5 minutes	Need for oxygenotherapy (yes/no)
Means of ventilation	5 minutes	Means of ventilation
Gasometry	5 minutes	Vital signs at hospital admission: Gasometry
CRP	5 minutes	CRP at hospital admission or first recorded

Trial Locations

Locations (1)

CHU Brugmann; 🇧🇪 Brussels, Belgium