Signal Analysis for Neurocritical Patients

Completed

• Conditions: Brain Injuries, Acute
• Interventions: Device: intracranial pressure monitoring

• Registration Number: NCT03362346
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

The project uses big data analysis techniques such as wavelet transform and deep learning to analyze physiological signals from neurocritical patients and build a model to evaluate intracranial condition and to predict neurological outcome. By identification of correlations among these parameters and their trends, we may achieve early detection of anomalies and enhance the ability in judgement of current neurological condition and prediction of prognosis. By continuous input of the past and contemporary data in the ICU, the model will be modified repeatedly and its accuracy improves as the model grows. The model can be used to recognize abnormalities earlier and provide a warning system. Clinicians taking care of neurocritical patients can adjust their treatment policy and evaluate the outcome according to such system.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-11-29
• Study First Submitted QC: 2017-12-04
• Study First Posted: 2017-12-05
• Study Start: 2017-12-18
• Primary Completion: 2018-05-24
• Study Completion: 2018-05-31
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-03
• Last Update Posted: 2018-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

• Age equal to or older than 20 years
• Neurocritical patients admitted to intensive care unit (ICU), including but not limited to traumatic brain injury, hemorrhagic stroke, ischemic stroke, brain infection, brain tumor and acute hydrocephalus.
• Patients who have undergone cranial surgery and had intracranial pressure monitor inserted or external ventricular drainage. The central monitor of ICU is able to collect the data continuously

Exclusion Criteria

• Age younger than 20 years.
• Continuous monitoring of intracranial pressure is not feasible.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Neurocritical patients	intracranial pressure monitoring	Patients with brain injury from trauma, ischemic stroke, hemorrhage stroke (intracerebral hemorrhage, subarachnoid hemorrhage), brain tumor with increased intracranial pressure, brain infection, hydrocephalus, among others.

Primary Outcome Measures

Name	Time	Method
Neurological status	Discharge out of the intensive care unit, averaged 2 weeks	Glasgow coma scale/Mortality

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 New Taipei City, Taiwan