Clinical Evaluation of Injectable Platelet Rich Fibrin With Connective Tissue Graft for the Treatment of Deep Gingival Recession Defects.

Not Applicable

Completed

• Conditions: Gingival Recession
• Interventions: Procedure: CAF+CTG+i-prf

• Registration Number: NCT04032405
• Lead Sponsor: Cukurova University

Brief Summary

Aim: The aim of this study was to determine whether the combined connective tissue graft (CTG) with injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF) improved root coverage of deep Miller Class I or II gingival recessions compared to CTG alone with CAF.

Methods: Seventy-two patients with Miller class I and II gingival recessions were enrolled. Thirty-six patients were randomly assigned to the test group (CAF+CTG+i-prf) or control group (CAF+CTG). Clinical evaluations were made at 6 months

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-01
• Primary Completion: 2018-09-25
• Study Completion: 2019-03-30
• Status Verified: 2019-07
• Study First Submitted: 2019-07-22
• Study First Submitted QC: 2019-07-23
• Last Update Submitted: 2019-07-23
• Study First Posted: 2019-07-25
• Last Update Posted: 2019-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• ≥19 years of age,
• Periodontally and systemically healthy,
• FMPS and FMBS <15%,
• Presence of deep Miller class I and II gingival recession defect (≥3 mm in depth) at the buccal aspect of incisors,

Exclusion Criteria

Smoking,

• Contraindications for surgery,
• Presence of recession defects associated with caries, deep abrasion, restoration or pulpal pathology.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CAF+CTG	CAF+CTG+i-prf	the combined connective tissue graft (CTG) with coronally advanced flap (CAF)
CAF+CTG+i-prf	CAF+CTG+i-prf	the combined connective tissue graft (CTG) and injectable platelet rich fibrin (i-prf) with coronally advanced flap (CAF)

Primary Outcome Measures

Name	Time	Method
Keratized tissue height	six months	measured from the mucogingival junction to the gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre
gingival recession depth	six months	the distance between the CEJ and gingival margin-measurements were performed at the midbuccal aspect of the teeth, by manual probe and were rounded up to the nearest millimetre

Trial Locations

Locations (1)

Cukurova University; 🇹🇷 Adana, Balcalı, Turkey