Clinical Relevance of the Salvage Treatment for Colorectal Neuroendocrine Tumors

Completed

• Conditions: Neuroendocrine Tumors; Rectal Neoplasms
• Interventions: Procedure: salvage treatment

• Registration Number: NCT06143605
• Lead Sponsor: Yanhong Deng

Brief Summary

we evaluated all related clinical and pathologic data of rectal NET cases, including the resection margin status, NET grading, and lymphovascular invasion status. Finally, the present study was aimed at (1) determining the risk factors for LN and distant metastases in colorectal NETs (2) clarifying the clinical significance of the salvage treatment for colorectal neuroendocrine tumors following initial endoscopic resection with positive resection margin status and (3) compare different salvage treatment of this uncommon disease through conducting a large, multi-center cohort study.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-30
• Primary Completion: 2022-12-30
• Study Completion: 2023-09-30
• Status Verified: 2023-11
• Study First Submitted: 2023-11-16
• Study First Submitted QC: 2023-11-16
• Last Update Submitted: 2023-11-16
• Study First Posted: 2023-11-22
• Last Update Posted: 2023-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 527

Inclusion Criteria

• within the age range of 18 to 65 years, diagnosed with rectal neuroendocrine tumors. Furthermore, patients were required to have a palpable tumor as determined by digital rectal examination or accessible through proctoscopy, with the distal border situated within 12 cm from the anal verge.

Exclusion Criteria

• (1) muscularis propria invasion or NET grading = 3, (2)regional LN or distant organs metastasis at the time of diagnosis, (3) incomplete follow-up information, (4) the patient had multiple primary tumors, (5) patients with surgical excision or inappropriate methods such as forceps removal, and (6) the patient had a history of malignant tumors.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
salvage treatment group	salvage treatment	patients with salvage treatment after endoscopic resection were diagnosed as having positive resection margin status

Primary Outcome Measures

Name	Time	Method
DFS	5 year	disease free survival