Research Study of Visilizumab for Treatment of Glucocorticoid- Refractory Graft Versus Host Disease
- Conditions
- Graft-vs-Host Disease
- Registration Number
- NCT00032279
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Brief Summary
The purpose of this phase II study is to evaluate an investigational monoclonal antibody for the treatment of glucocorticoid-refractory Graft Versus Host Disease (GVHD). Patients diagnosed with GVHD who have not responded satisfactorily to, or are intolerant of, treatment with standard agents will be considered for entry. Patients will be allowed to continue on their other immunosuppressive drugs at stable doses during the trial. The research is being conducted at up to 20 clinical research sites in the US.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (17)
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Dana Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
City of Hope National Medical Center
🇺🇸Duarte, California, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Washington University School of Medicine
🇺🇸St. Louis, Missouri, United States
Westchester Medical Center
🇺🇸Valhalla, New York, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
H. Lee Moffitt Cancer Center & Research Institute
🇺🇸Tampa, Florida, United States
Ohio State University
🇺🇸Columbus, Ohio, United States
Duke University
🇺🇸Durham, North Carolina, United States
University of Massachusetts Medical School
🇺🇸Worcester, Massachusetts, United States
Stanford University Medical Center
🇺🇸Stanford, California, United States
University Hospital
🇺🇸Indianapolis, Indiana, United States
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
The New York Hospital Cornell Medical Center
🇺🇸New York, New York, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States