Phase II multicenter study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma
- Conditions
- Neoplasms
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 71
1. Male or female patients = 18 years of age
2. Intitially diagnosed or recurrent hepatocellular carcinoma (HCC)
3. Unresectable HCC
4. Cirrhotic status of Child Pugh class A or B7
5. Eastern Cooerative Oncology Group performance status 0 or 1
6. Tumor size < 10cm
7. The volume of uninvolved must be at least 1000 ml
8. Incomplete response after trans-arterial chemo-embolization of 1-5
9. A single lesion or multiple lesions including portal vein tumor thrombosis included in radiation field with one or consecutive sesseions of SBRT
10. No evidence of an uncontrolled lesion at any other site
11. No evidence of complications of liver cirrhosis
12. No evidence of uncontrolled inter-current illness
13. Patient or gaurdian must be able to provide verbal and written informed consent
1. Patient with previous history of abdominal radiation
2. Direc invasion to esophagus, stomach or colon by HCC
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ocal control rate;Severe treatment related toxicity
- Secondary Outcome Measures
Name Time Method Overal survival;Progression free survival;Patterns of failure;Intrahepatic recurrence free survival