Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Phase 4

• Conditions: Preterm Birth; Preeclampsia; Twin Pregnancy; Fetal Growth Restriction
• Interventions: Drug: Aspirin 100mg

• Registration Number: NCT04051567
• Lead Sponsor: Ministry of Science and Technology of the People´s Republic of China

Brief Summary

Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-01
• Study First Submitted: 2019-07-09
• Study First Submitted QC: 2019-08-08
• Study First Posted: 2019-08-09
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-25
• Last Update Posted: 2019-10-29
• Primary Completion: 2020-06-01
• Study Completion: 2020-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 425

Inclusion Criteria

• Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w

Exclusion Criteria

• Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LDA group	Aspirin 100mg	-

Primary Outcome Measures

Name	Time	Method
The incidence of preeclampsia, preterm birth, fetal growth restriction	after 30 weeks of gestional age

Trial Locations

Locations (1)

Hongbo,Qi; 🇨🇳 Chongqing, Chongqing, China