Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Renal Blood Flow (RBF)
研究概览
简要总结
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
详细描述
After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preserved left ventricular function (LVEF > 50%)
- •Normal preoperative S-creatinine
排除标准
- •Contraindications to radiocontrast
- •Cardiac transplantation och dissection
结局指标
主要结局
Renal Blood Flow (RBF)
时间窗: 6 hours
Renal blood flow measured with PAH clearance
Glomerular Filtration Rate (GFR)
时间窗: 6 hours
GFR measured by renal extraction of 51Cr-EDTA
Renal Oxygenation
时间窗: 6 hours
Renal oxygen extraction, defined as renal oxygen consumption divided by renal oxygen delivery
次要结局
- Development of Acute Kidney Injury (AKI)(72 hours)
- Excretion of NAG(24 hours)
研究者
Lukas Lannemyr
MD
Sahlgrenska University Hospital, Sweden