Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Complication of Extracorporeal Circulation
- Sponsor
- Sahlgrenska University Hospital, Sweden
- Enrollment
- 28
- Locations
- 1
- Primary Endpoint
- Renal Blood Flow (RBF)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
Detailed Description
After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses
Investigators
Lukas Lannemyr
MD
Sahlgrenska University Hospital, Sweden
Eligibility Criteria
Inclusion Criteria
- •Preserved left ventricular function (LVEF \> 50%)
- •Normal preoperative S-creatinine
Exclusion Criteria
- •Contraindications to radiocontrast
- •Cardiac transplantation och dissection
Outcomes
Primary Outcomes
Renal Blood Flow (RBF)
Time Frame: 6 hours
Renal blood flow measured with PAH clearance
Glomerular Filtration Rate (GFR)
Time Frame: 6 hours
GFR measured by renal extraction of 51Cr-EDTA
Renal Oxygenation
Time Frame: 6 hours
Renal oxygen extraction, defined as renal oxygen consumption divided by renal oxygen delivery
Secondary Outcomes
- Development of Acute Kidney Injury (AKI)(72 hours)
- Excretion of NAG(24 hours)