Pain Perception in Suicidal Behavior Vulnerability
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 167
- 试验地点
- 1
- 主要终点
- Pain tolerance reported by the patient
研究概览
简要总结
In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.
The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.
The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.
After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).
详细描述
242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)
First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged by 18 years old
- •came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
- •main diagnosis of major depressive episode (DSM V criteria)
- •not having take antalgics in the 24 hours before assessment
- •received a minimal psychotrope treatment (clinician evaluation)
- •Able to understand nature, aims, methodology of the study
- •Agree to cooperate in clinical and biological assessment
- •Having signed informed consent
- •Specific inclusion criteria :
- •81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)
排除标准
- •Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
- •Current algic and chronic neurologic disease
- •Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
- •Pregnancy
- •Patients on protective measure
研究组 & 干预措施
Study participant
All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation:
- 81 depressed patients admitted after a recent suicidal act (<8 days)
- 81 depressed subjects with a past history of suicidal act (>1month)
- 80 depressed subjects without any personal history of suicidal behaviour
干预措施: Blood sample for genetic purpose, psychiatric assessment and pain investigation (Other)
结局指标
主要结局
Pain tolerance reported by the patient
时间窗: During thermal stimulation
temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
次要结局
- Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)(At the inclusion)
- Psychological pain intensity(At V2 (one week maximum after the inclusion))
- Social distress perception assessed by social distress questionnaire(At V2 (one week maximum after the inclusion))
- Measure of cardiac frequency in response to thermal pain(At V2 (one week maximum after the inclusion))
- Kinetics of pain intensity(During thermal stimulation performed at the inclusion)
- Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)(At the inclusion)
- Pain intensity reported by the patient(During thermal stimulation)
- Pain threshold reported by the patient(During thermal stimulation)
- Temperature assessed at 4/10 on likert scale(During thermal stimulation performed at the inclusion)