Pain Perception in Suicidal Behavior Vulnerability
- Conditions
- Major Depressive Episode
- Interventions
- Other: Blood sample for genetic purpose, psychiatric assessment and pain investigation
- Registration Number
- NCT02915679
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.
The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.
The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.
After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).
- Detailed Description
242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)
First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 167
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Study participant Blood sample for genetic purpose, psychiatric assessment and pain investigation All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation: * 81 depressed patients admitted after a recent suicidal act (\<8 days) * 81 depressed subjects with a past history of suicidal act (\>1month) * 80 depressed subjects without any personal history of suicidal behaviour
- Primary Outcome Measures
Name Time Method Pain tolerance reported by the patient During thermal stimulation temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
- Secondary Outcome Measures
Name Time Method Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ) At the inclusion comparison between the three groups of the score of social distress scale after cyberball game
Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ) At the inclusion comparison between the three groups of the score of social rejection sensitivity by RSQ
Psychological pain intensity At V2 (one week maximum after the inclusion) comparison between the three groups of the score of psychological pain intensity assessed by VAS scale.
Social distress perception assessed by social distress questionnaire At V2 (one week maximum after the inclusion) comparison between the three groups of the score of social distress scale after cyberball game
Measure of cardiac frequency in response to thermal pain At V2 (one week maximum after the inclusion) comparison between the three groups of the cardiac frequency.
Kinetics of pain intensity During thermal stimulation performed at the inclusion comparison between the three groups of kinetics of pain intensity by visual analog scale (VAS) scale.
Pain intensity reported by the patient During thermal stimulation comparison between the three groups of the pain intensity (assessed by likert scale) at constant temperature (43 ° C)
Pain threshold reported by the patient During thermal stimulation comparison between the three groups of the pain threshold (temperature perceived as painful)
Temperature assessed at 4/10 on likert scale During thermal stimulation performed at the inclusion comparison between the three groups of the temperature assessed at 4/10 on a visual analogic painful scale, kinetics of pain intensity by visual analog scale (VAS) scale.
Trial Locations
- Locations (1)
Montpellier Hospital University
🇫🇷Montpellier, France