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Clinical Trials/NCT04338503
NCT04338503
Recruiting
Not Applicable

Mechanically Optimizing Cardiac Preload Using Partial Inferior Vena Cava Occlusion to Reduce Pulmonary Pressures in Heart Failure Patients in Heart Failure Patients

Cardioflow Technologies, LLC1 site in 1 country10 target enrollmentSeptember 1, 2021
ConditionsHeart Failure

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Heart Failure
Sponsor
Cardioflow Technologies, LLC
Enrollment
10
Locations
1
Primary Endpoint
Change in pulmonary arterial pressures
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

The purpose of the current study is to determine if partial balloon occlusion of the inferior vena cava can optimize cardiac pre-load and subsequently pulmonary pressures and cardiac output as a novel method to unload pulmonary edema and other symptoms of decompensated congestive heart failure. All products in this study are FDA approved and adhere to the specifications of the intended use.

Registry
clinicaltrials.gov
Start Date
September 1, 2021
End Date
June 30, 2024
Last Updated
3 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Subjects scheduled to undergo a right heart catheterization at Saint Thomas Hospital.
  • New York Heart Association (NYHA) II or III.
  • Subjects must be last least 18 years of age.
  • A left ventricular ejection fraction \>= 20%.
  • Pulmonary artery occlusion pressure, or pulmonary wedge pressure \>20 mmHg.

Exclusion Criteria

  • Subjects without sinus rhythm.
  • Evidence of right heart failure.
  • Patients with primary pulmonary hypertension
  • Pulmonary wedge pressure \<15mmHg.
  • Significant lung disease, such as prior diagnosis of COPD.
  • Resting or dynamic outflow tract gradient
  • Patients with left bundle branch block

Outcomes

Primary Outcomes

Change in pulmonary arterial pressures

Time Frame: During partial balloon occlusion

Change in the measured mean pulmonary arterial pressure

Secondary Outcomes

  • Change in cardiac output(During partial balloon occlusion)

Study Sites (1)

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