Brain Effects of Sacral Neuromodulation
Not Applicable
Completed
- Conditions
- Urinary Tract Disease
- Interventions
- Radiation: Baseline neuroimagingRadiation: Neuroimaging during sacral neuromodulation
- Registration Number
- NCT00610064
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Brief Summary
Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood.
We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Patients with refractory lower urinary tract dysfunction scheduled for sacral neuromodulation
Exclusion Criteria
- Pregnancy
- Age <18 years
- Claustrophobia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description A Baseline neuroimaging Baseline neuroimaging B Neuroimaging during sacral neuromodulation Neuroimaging during sacral neuromodulation
- Primary Outcome Measures
Name Time Method Effect of sacral neuromodulation on brain activity 2-8 weeks
- Secondary Outcome Measures
Name Time Method Differences in brain activity effects of sacral neuromodulation (SNM) in patients with successful compared to failed SNM testing immediately and 2-8 weeks after study inclusion
Trial Locations
- Locations (1)
Department of Urology, University of Bern
🇨ðŸ‡Bern, Switzerland