Brain Effects of Sacral Neuromodulation in Patients With Refractory Lower Urinary Tract Dysfunction

Insel Gruppe AG, University Hospital Bern1 site in 1 country30 target enrollmentOctober 2005

ConditionsUrinary Tract Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Urinary Tract Disease
Sponsor: Insel Gruppe AG, University Hospital Bern
Enrollment: 30
Locations: 1
Primary Endpoint: Effect of sacral neuromodulation on brain activity
Status: Completed
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood.

We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).

Registry

clinicaltrials.gov

Start Date

October 2005

End Date

June 2009

Last Updated

16 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Insel Gruppe AG, University Hospital Bern

Eligibility Criteria

Inclusion Criteria

•Patients with refractory lower urinary tract dysfunction scheduled for sacral neuromodulation

Exclusion Criteria

•Pregnancy
•Age \<18 years
•Claustrophobia

Outcomes

Primary Outcomes

Effect of sacral neuromodulation on brain activity

Time Frame: 2-8 weeks

Secondary Outcomes

Differences in brain activity effects of sacral neuromodulation (SNM) in patients with successful compared to failed SNM testing(immediately and 2-8 weeks after study inclusion)