Observational study to characterize the pathogenesis of acute-on-chronic liver failure

Recruiting

• Conditions: K74.2; K72.1; Hepatic fibrosis with hepatic sclerosis; Chronic hepatic failure

• Registration Number: DRKS00022124
• Lead Sponsor: Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

SAPIENT: ACLF with Need for intensive care

PROACT: ACLF with indication for TIPS

ELITE: ALCF with indication for liver transplantation

Exclusion Criteria

- HCC outside MILAN criteria or other malignoma

- hereditary or acquired immune deficiency

- pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality - surveillance of the clinical courses of ACLF patients in each of the three study arms and survival analysis (28-day, 90-day, and 1-year mortality)