Innovative Technology Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 396
- 主要终点
- overall survival
研究概览
简要总结
The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this technique. The primary research question it seeks to investigate is:
"What are the differences in safety and efficacy between auxiliary liver transplantation utilizing small-for-size grafts and conventional liver transplantation for the treatment of portal hypertension?"
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 14 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 14 years.
- •Presence of decompensated portal hypertension.
- •Meeting the indications for liver transplantation surgery.
- •International Normalized Ratio (INR) < 2.
- •Scheduled to undergo orthotopic auxiliary partial liver transplantation or conventional liver transplantation.
排除标准
- •Rare liver-related anatomical variations.
- •Presence of contraindications to liver transplantation combined with malignant tumors.
- •Grade III or higher portal vein thrombosis.
- •Severe systemic diseases unrelated to the etiology or complications of portal hypertension.
- •Special surgical procedures such as dual-graft liver transplantation.
- •Special graft sources including domino liver transplantation.
- •Liver re-transplantation.
研究组 & 干预措施
auxiliary liver transplantation using small-for-size grafts
conventional liver transplantation using Standard-size graft
结局指标
主要结局
overall survival
时间窗: Within one year after liver transplantation
Complications
时间窗: Within one year after liver transplantation
portal hypertension resolution
时间窗: Within one year after liver transplantation
次要结局
未报告次要终点
研究者
Zhi-Jun Zhu
Principal Investigator
Beijing Friendship Hospital