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Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder

Phase 3
Registration Number
CTRI/2009/091/000360
Lead Sponsor
Allergan, Inc.
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Open to Recruitment
Sex
Not specified
Target Recruitment
135
Inclusion Criteria

Urinary incontinence as a result of neurogenic overactive bladder
due to spinal cord injury or multiple sclerosis
- Inadequate response to anticholinergic medication used to treat
overactive bladder.
- Respiratory impairment and abnormal pulmonary function test
results

Exclusion Criteria

- History or evidence of pelvic or urologic abnormality
- Previous or current diagnosis of bladder or prostate cancer
- Symptomatic or untreated urinary tract infection at time of
enrollment

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Forced Expiratory VolumeTimepoint: Week 2;Forced Vital CapacityTimepoint: Week 2
Secondary Outcome Measures
NameTimeMethod
Maximum cystometric capacity (urodynamics)Timepoint: Weeks 2 - 52;Number of episodes of urinary incontinence (urodynamics)Timepoint: Weeks 2 - 52;Peak (amplitude) detrusor pressure (urodynamics)Timepoint: Weeks 2-52;Pulmonary functionTimepoint: Weeks 2 - 52
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