Characterisation of the immune response after spinal cord injury

Recruiting

• Conditions: Spinal cord injury; 10041543

• Registration Number: NL-OMON55320
• Lead Sponsor: niversiteit Hasselt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 102

Inclusion Criteria

- Age >= 18 years
- Recently diagnosed with SCI, i.e. not more than 8 weeks prior to admission to
the rehabilitation center

Exclusion Criteria

- Incapacitated patients
- Patients with pre-existing autoimmune disorders
- Patients who receive anti-inflammatory or immune modulatory treatment (e.g.
corticosteroid administration)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Identification of the autoantibodies produced after SCI.<br /><br>- Characterisation of the autoantibody response after SCI in patients over time.<br /><br>- Assessment of the association between clinical outcome parameters and changes<br /><br>in antibody levels: determining the prognostic biomarker potential of the<br /><br>candidate biomarkers.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Determine immune cell subtypes and function, immune derivatives, inflammatory<br /><br>and neurological markers in peripheral blood at multiple time points following<br /><br>spinal cord injury.<br /><br>- Assessment of the association between the clinical outcome parameters and the<br /><br>changes in immunological and neurological parameters in SCI patients.</p><br>