Effect of Physical Strength Exercise on Telomeric Length as a Marker of Aging and Early Death in Patients With Schizophrenia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- University of Salamanca
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- Telomere Length
Study Overview
Brief Summary
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly distributed into two groups (intervention and control).
The main objective of the study is to determine the effect of physical exercise on telomere size in patients diagnosed with schizophrenia.
As secondary objectives in this group of patients we will try to:
Evaluate the influence of strength training on cognition and negative symptoms of schizophrenia.
To quantify the impact of strength training on frailty. To determine the effect of strength training on quality of life. To study the possible correlation between physical parameters (frailty) and telomere length.
To establish the importance of polymorphisms in telomerase genes, an enzyme involved in the maintenance of telomere length.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- Single (Outcomes Assessor)
Masking Description
The persons in charge of the evaluation of the participants will be unaware of the assignment of the participants.
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •be at least 18 years of age
- •have been diagnosed with schizophrenia for at least 5 years
Exclusion Criteria
- •are unable to read and understand the patient information sheet and sign the informed consent form.
Outcomes
Primary Outcomes
Telomere Length
Time Frame: Baseline and immediately after the intervention
Telomere length will be measured before and after the procedure in kilobases.
Secondary Outcomes
- Cognition(Baseline and immediately after the intervention)
- Sex(Baseline)
- Fragility(Baseline and immediately after the intervention)
- Date of birth(Baseline)
- Quality of life(Baseline and immediately after the intervention)
- Heighth(Baseline)
- Negative Symptoms(Baseline and immediately after the intervention)
Investigators
Juan Luis Sanchez Gonzalez
Principal Investigator. Juan Luis Sánchez González
University of Salamanca