Physical Exercise in Patients With Schizophrenia
- Conditions
- SchizophreniaPremature AgingPhysical ActivityTelomere Shortening
- Interventions
- Other: Normal lifeOther: Strength physical exercise programme
- Registration Number
- NCT05978921
- Lead Sponsor
- University of Salamanca
- Brief Summary
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly distributed into two groups (intervention and control).
The main objective of the study is to determine the effect of physical exercise on telomere size in patients diagnosed with schizophrenia.
As secondary objectives in this group of patients we will try to:
Evaluate the influence of strength training on cognition and negative symptoms of schizophrenia.
To quantify the impact of strength training on frailty. To determine the effect of strength training on quality of life. To study the possible correlation between physical parameters (frailty) and telomere length.
To establish the importance of polymorphisms in telomerase genes, an enzyme involved in the maintenance of telomere length.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 40
- be at least 18 years of age
- have been diagnosed with schizophrenia for at least 5 years
- are unable to read and understand the patient information sheet and sign the informed consent form.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Normal life Subjects in the control group will continue with their normal life and carry out all the activities they have been doing previously. Intervention group Strength physical exercise programme An additional strength training programme will be carried out for 12 weeks with 2 sessions per week. The sessions will last approximately 50 minutes and will be divided into 3 distinct parts: The first part will consist of a warm-up with a part of aerobic exercise that will last approximately 15 minutes. This will be followed by the main part of strength training with a circuit of 6 exercises (3 series x 12 repetitions) which will last approximately 25 minutes. Finally, there will be a cool down phase with breathing exercises to allow people to recover.
- Primary Outcome Measures
Name Time Method Telomere Length Baseline and immediately after the intervention Telomere length will be measured before and after the procedure in kilobases.
- Secondary Outcome Measures
Name Time Method Sex Baseline It will be registered at the beginning of the study.
Cognition Baseline and immediately after the intervention Cognition will be measured using the Brief Assessment of Cognition in Schizophrenia (BACS).The maximum and minimum score on the Brief Assessment of Cognition in Schizophrenia (BACS) is 100 points and the minimum possible score is 0 points. The scoring scale is based on the performance of a normative reference group, where the mean is set at 100 and the standard deviation at 15. Thus, a score of 100 indicates average performance within the normative population, while a higher score would be considered above average and a lower score below average.
Fragility Baseline and immediately after the intervention Fragility will be measured using the Short Physical Performance Battery scale (SPPB). SPPB scores range from zero to 12 possible points. SPPB score of 3-9 points in persons with possible sarcopenia but no mobility disability indicates frailty; SPPB score of 10 or greater for persons with no sarcopenia and no mobility disability indicates robustness. Persons with a score of 2 or lower who have sarcopenia, potential cachexia, and mobility disability are determined to be disabled.
Date of birth Baseline It will be registered at the beginning of the study in order to calculate the age of the participant.
Quality of life Baseline and immediately after the intervention Quality of life will be assessed using the EuroQuality of Life (EQ-5D-5L scale). This scale is numbered from 0 to 100. • 100 means the best health you can imagine. 0 means the worst health you can imagine.
Heighth Baseline It will be registered at the beginning of the study in centimeters.
Negative Symptoms Baseline and immediately after the intervention Negative symptoms of the disease will be measured and assessed using the Brief Negative Symptom Scale (BNSS). The BNSS is comprised of 13 questions organized into 6 subscales that assess anhedonia, distress, asociality, avolition, blunted affect, and alogia. Items are scored on a 0 to 6 scale, with 0 indicating the symptom is absent and 6 indicating the symptom is severe
Trial Locations
- Locations (1)
Universidad de Salamanca
🇪🇸Salamanca, Castilla Y León / Salamanca, Spain