Comparison Between Standard Dose Methyl Prednisolone and Megadose Methyl Prednisolone as Regards Outcome in SARS.COV.2 Patients in Intensive Care Unit : Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 2
- 主要终点
- 28 days mortality rate
研究概览
简要总结
aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.
详细描述
Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.
Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy
排除标准
- •Not requiring oxygen therapy
- •Negative PCR
- •Uncontrolled blood sugar or DKA
- •Patients on long term steroids therapy
结局指标
主要结局
28 days mortality rate
时间窗: 1 month
observation for mortality rate in both groups
次要结局
- mechanical ventilation and icu length of stay(up to 3 months)
研究者
Amr M Hilal Abdou
Assistant Professor
Ain Shams University