Comparison Between Different Doses of Steroids in COVID-19 Patients

Completed

• Conditions: Critical Illness; Pneumonia, Viral
• Interventions: Other: observation for outcome of methylprednisolone dose

• Registration Number: NCT05279482
• Lead Sponsor: Ain Shams University

Brief Summary

aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Detailed Description

Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.

Study Timeline

• Study Start: 2022-01-19
• Status Verified: 2022-03
• Primary Completion: 2022-03-01
• Study Completion: 2022-03-09
• Study First Submitted: 2022-03-10
• Study First Submitted QC: 2022-03-12
• Last Update Submitted: 2022-03-12
• Study First Posted: 2022-03-15
• Last Update Posted: 2022-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy

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Exclusion Criteria

• Not requiring oxygen therapy
• Negative PCR
• Uncontrolled blood sugar or DKA
• Patients on long term steroids therapy

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group treated with standard dose methyl prednisolone	observation for outcome of methylprednisolone dose	patients with positive PCR and requiring oxygen therapy
group treated with mega dose methyl prednisolone	observation for outcome of methylprednisolone dose	patients with positive PCR and requiring oxygen therapy

Primary Outcome Measures

Name	Time	Method
28 days mortality rate	1 month	observation for mortality rate in both groups

Secondary Outcome Measures

Name	Time	Method
mechanical ventilation and icu length of stay	up to 3 months	observation for percentage of mechanically ventilated patients and length of stay

Trial Locations

Locations (2)

Ain shams university hospitals; 🇪🇬 Cairo, Egypt

Faculty of medicine, Ain Shams University; 🇪🇬 Cairo, Egypt