NCT00141583终止不适用
The Renin-Angiotensin System in Essential Hypertension
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Change in BP
研究概览
简要总结
Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Essential Hypertension
- •SBP 140-159 mmHg
- •DBP 90-99 mmHg
排除标准
- •Intolerance of or allergy to ACE Inhibitors or ARBS
- •Pregnant or Breastfeeding
- •Pre-menopausal women
- •Uncontrolled cardiac or renal failure
- •Diabetes mellitus
结局指标
主要结局
Change in BP
Change in PRA and aldosterone
次要结局
未报告次要终点
研究者
研究点 (2)
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